Due to the rapid spread of the outbreak, the Central Board of Muhammadiyah declares that centered solemn and massive prevention and actions are vital to fight against the pandemic. Muhammadiyah urges government to engage all elements to go hand in hand, promote how to prevent the spread of the COVID-19, and make open and comprehensive policy. Muhammadiyah has established Muhammadiyah COVID-19 Command Center (MCCC) that functions to formulate and undertake programs to tackle COVID-19. Therefore, collaboration of all elements is crucial to succeed the programs. It is expected that all Muhammadiyah majlis, boards, and autonomous organizations to work together to cope with the COVID-19 outbreak under the command of the MCCC. They may also take roles in gathering funds and managing aid distributions.